Dr. Martin Stieler

I learned the method of protein crystallography during my doctorate in medicinal chemistry at the Philipps University of Marburg (AG Klebe) and then established it in a biotech company in Darmstadt. Here, as head of structural biology, I was responsible for the structural biology part for several years regarding the development of a reversible transglutaminase inhibitor for the treatment of diabetic nephropathy (project details). I would like to pass on the experience and knowledge that I was able to gather during my 10 years of professional experience in the field of structural biology to you and support you in establishing this method in your company.

I'm convinced: If there was greater awareness about how easy it is to work with protein crystallography in your own company, many more companies would use this method.

I am aware of the sensitivity of your data and results. I'd be happy to sign a non-disclosure agreement.

I am looking forward to getting to know you personally.

Martin Stieler

Publications & patents

Stieler, M., Büchold, C., Schmitt, M., Heine, A., Hils, M., Pasternack, R., Klebe, G. Structure-Based Design of FXIIIa Blockers: Addressing a Transient Hydrophobic Pocket in the Active Site of FXIIIa, ChemMedChem 2020, 15, 900.
Stieler, M., Weber, J., Hils, M., Kolb, P., Heine, A., Büchold, C., Pasternack, R., Klebe, G. Structure of Active Coagulation Factor XIII Triggered by Calcium Binding: Basis for the Design of Next Generation Anticoagulants, Angewandte Chemie Int. Ed. 2013, 52, 11930.

Schiebel, J., Krimmer, S. G., Röwer, K., Knörlein, A., Wang, X., Park, A. J., Stieler, M., Ehrmann, R. F., Fu, K., Radeva, N., Krug, M., Huschmann, F. U., Glöckner, S., Weiss, M. S., Mueller, U., Klebe, G., Heine, A. High-Throughput Crystallography: Reliable and Efficient Identification of Fragment Hits, Structure 2016, 24, 1398.
Radeva, N., Schiebel, J., Wang, X. J., Krimmer, S. G., Fu, K., Stieler, M., Ehrmann, F. R., Metz, A., Rickmeyer, T., Betz, M., Winquist, J., Park, A. Y., Huschmann, F. U., Weiss, M. S., Mueller, U., Heine, A., Klebe, G. Active Site Mapping of an Aspartic Protease by Multiple Fragment Crystal Structures: Versatile Warheads To Address a Catalytic Dyad, J Med Chem 2016, 59, 9743.
Martin Hils, Ralf Pasternack, Christian Büchold, Johannes Weber, Andreas Heine, Gerhard Klebe, Martin Stieler; Crystal structure of blood coagulation factor xiiia, WO2014090835A1.

Presentations

Calcium-Induced Activation of FXIII and Structure-Based Design of Direct Acting Inhibitors
25th International Fibrinogen Workshop, Winston-Salem (USA), 2018
The Next Generation Anticoagulant: Structure-Based Design of a Factor XIII Blocker
Annual Meeting of the Society of Thrombosis and Hemostasis Research, Düsseldorf, 2015
Crystal Structure of Blood Coagulation Factor XIII in the Active Conformation
Gordon Research Conference – Transglutaminases in Human Disease Processes, Lucca (Italy), 2014

Miscellaneous

Article: Design of Oral FXIIIa Blockers as Safer Anticoagulants – Mission Impossible?
Website Zedira GmbH, 2020
Protein structures deposited in the Protein Data Bank (PDB)

Additional information about me can be found on LinkedIn.

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